The discovery of active peptide in Laba garlic

At present, many new active peptides have been found for the first time in the traditional Chinese food "Laba Garlic". These active peptides have significant bacteriostasis and are expected to become alternatives to antibiotics. Relevant results have been published in the international scientific journal Food Function.

The discovery and application of antibiotics is a great revolution in the history of human medicine. However, with the widespread use of antibiotics in clinic, there are abuse and misuse of antibiotics in many countries. Drug abuse makes bacteria quickly adapt to antibiotic environment, and various "superbacteria" have been born one after another, which seriously endangers people's health. Searching for safe and effective antibiotic substitutes is one of the effective ways to solve the global medical problem of bacterial resistance.

Active peptides are called "chemical messengers" in animals and plants, which regulate the growth, development, reproduction, metabolism and behavior of organisms. Professor Chen Haixia's team has long focused on the health and therapeutic effects of various functional ingredients in food. This time, they found and identified three new active peptides in the traditional Chinese food "Laba Garlic", and studied their bacteriostatic activity and mechanism. Studies have shown that these active peptides can form channels on the surface of bacterial cells, destroy bacterial cell membranes and cause leakage of cell contents by using the mechanism of "barrel channel model" and "carpet model" to inhibit bacteria.

"The extensive biological activity of the new active peptide shows its good application prospect in medicine." Dr. Gao Xudong of the team introduced that the new active peptide not only has good antimicrobial activity, but also has the characteristics of low toxicity and not easy to produce drug-resistant bacteria. It is expected to become a safe and effective alternative to antibiotics suitable for human body. The relevant research results provide a theoretical basis for further development and application of natural antimicrobial peptide drugs.